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MasterClassThe Professor
I'm a Professor of Neuroscience and Biomedical Engineering at UT Dallas, where I founded and direct the Sleep Innovation Laboratories at the Center for BrainHealth. My lab studies how sleep shapes human health and disease — from Alzheimer's and cardiovascular illness to depression, anxiety, and metabolic function.
Before Texas, I spent seventeen years at UC Berkeley, and before that I was Professor of Psychiatry at Harvard Medical School. A hundred-plus peer-reviewed papers, funded by the NIH and NSF. The work has always been the same question, asked from different angles: what does sleep actually do, and what happens when it doesn't happen?
BSc Neuroscience
Nottingham University, UK
PhD Neurophysiology
Medical Research Council, London
Professor of Psychiatry
Harvard Medical School
Professor of Neuroscience & Psychology
UC Berkeley
Lorri & Todd Platt Professor of Neuroscience & Biomedical Engineering
Sleep Innovation Laboratories, Center for BrainHealth — UT Dallas — Current
100+
Peer-reviewed publications
25M+
TED talk views
4M+
Books sold, 40+ languages
17 yrs
UC Berkeley faculty
Research Methodology
The lab works across the full translational pipeline — MRI, PET, high-density sleep EEG, genomics, proteomics, autonomic physiology, transcranial stimulation, and cognitive testing — moving from basic neuroscience discovery to clinical intervention and real-world application.
The Author
“The best bridge between despair and hope is a good night’s sleep.”
The Public Intellectual
Most of the research that matters never leaves the journals. I've spent the last decade trying to change that — on stages, on podcasts, in the ear of anyone who'll listen. My TED talk, Sleep Is Your Superpower, has crossed 25 million views on TED.com alone, making it one of the most-watched science talks in TED history.
I've given keynotes at Goldman Sachs, U.S. Special Operations Command, the Society for Neuroscience, Equinox Hotels, and the Center for BrainHealth. My MasterClass on the Science of Better Sleep has reached millions of students worldwide.
Top Appearances by YouTube Views
YouTube views across all listed appearances (51.7M) plus TED.com plays (25.9M). Clips and shorts included where noted. Figures as of April 2026.
25M+ views. One of the most-watched science talks in TED history.
Hover to see all episodes →
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5-star rated. Leading neuroscientists, clinicians, and athletes.
Speaking Venues
Represented by the Harry Walker Agency. Available for keynotes, corporate workshops, and medical grand rounds on sleep science, performance optimization, and public health.
The Entrepreneur
Two companies. Both are attempts to get laboratory findings past the laboratory door.
Co-Founder
A neurotechnology headband that delivers personalized transcranial alternating current stimulation tuned to each wearer's own brainwaves — enhancing natural sleep architecture rather than overriding it. Developed with Professors Robert Knight and Richard Ivry at UC Berkeley, and published in Frontiers in Human Neuroscience.
Founder & CEO
Private. By introduction.
A concierge practice for a small number of clients each year. The intake is clinical, the analysis is personal, and the consultation is conducted privately by Dr. Walker alongside a board-certified sleep medicine doctor and in conjunction with a certified behavioural sleep medicine clinician, all in accordance with validated clinical protocols.
There is no public tier list. Admissions are by introduction, the details of which the client is welcome to share through direct inquiry, below. Currently the practice is full. At present, waitlist timeline is 7 months.
Strategic Partnerships
NREM and REM each play distinct, complementary roles in stabilizing new memories and integrating them into what you already know.
The effect extends to motor learning, declarative recall, and creative problem-solving.
Sleep loss amplifies amygdala reactivity and weakens prefrontal control, with direct bearing on anxiety, depression, and PTSD.
REM appears to recalibrate those circuits overnight — separating the content of emotional memories from their charge.
Disrupted deep NREM sleep is associated with beta-amyloid accumulation, and amyloid buildup in turn degrades sleep — a self-reinforcing loop.
Sleep is emerging as both an early biomarker and a possible therapeutic target for neurodegenerative disease.
Fragmented and insufficient sleep is associated with arterial stiffening, altered glucose regulation, and elevated cardiovascular risk.
Even modest disruption changes blood-vessel physiology and insulin sensitivity at a mechanistic level.
Work with Vallat and Shah showing how fragmented sleep elevates inflammatory markers and shifts the population dynamics of key immune cells.
A mechanistic bridge between poor sleep and the inflammation-driven diseases it tracks alongside.
Work with Krause showing that sleep loss amplifies pain sensitivity by disengaging prefrontal regions that normally regulate nociceptive signals.
The brain without sleep perceives pain more intensely — a finding with clinical implications for chronic pain management.
Work with Greer showing that short sleep elevates hunger hormones and biases food choice toward high-calorie, energy-dense items.
A plausible contributor to the relationship between chronic short sleep and weight gain.
Short sleep is associated with increased loneliness and reduced willingness to help, effects that appear across individuals, groups, and whole societies.
Sleep turns out to be a quietly social phenomenon as well as a personal one.
Take Dr. Walker's Four Macros of Good Sleep
Decades of clinical and experimental research distilled into four measurable dimensions. These are the four macros of good sleep — the metrics that determine whether your sleep is truly restorative.
Q
7–9 hrs
The CDC recommends 7–9 hours for adults. Infants need 15–16 hours, children 9–12, and teens 8–10.
Q
Efficiency
Sleep efficiency — the percentage of time in bed actually spent asleep. Beyond that, the depth and amount of deep NREM sleep and adequate REM cycles.
R
±20 min
49% decrease in all-cause mortality, 39% reduction in cancer mortality for the most regular sleepers.
T
Chronotype
Sleep aligned with your chronotype: Owl (late), Lark (early), or Neutral.